Research progress in drugs targeting 5-lipoxygenase for age-related diseases / 生理学报
Acta Physiologica Sinica
; (6): 864-876, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1007796
Responsible library:
WPRO
ABSTRACT
With the acceleration of aging society, delaying aging or promoting healthy aging has become a major demand for human health. 5-Lipoxygenase (5-LOX) is a key enzyme catalyzing arachidonic acid into leukotrienes (LTs), which is a potent mediator of the inflammatory response. Previous studies showed that abnormal activation of 5-LOX and overproduction of LTs are closely related to the occurrence and development of aging-related inflammatory diseases. Therefore, inhibiting 5-LOX activation is a possibly potential strategy for treating age-related diseases. In this paper, the latest research progress in 5-LOX activation, 5-LOX in mediating aging-related diseases and its small molecule inhibitors is briefly reviewed to provide scientific theoretical basis and new ideas for the prevention and treatment of aging-related inflammatory diseases.
Full text:
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Index:
WPRIM
Main subject:
Arachidonate 5-Lipoxygenase
/
Aging
/
Leukotrienes
/
Lipoxygenase Inhibitors
/
Arachidonic Acid
Limits:
Humans
Language:
Zh
Journal:
Acta Physiologica Sinica
Year:
2023
Type:
Article