Clinicopathological and immunohistochemical analysis of maxillofacial granular cell tumor / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 414-420, 2023.
Article
in En
| WPRIM
| ID: wpr-1007922
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To analyze the clinicopathological features of maxillofacial granular cell tumors (GCT) with the aid of immunohistochemical staining.@*METHODS@#Seven cases of maxillofacial GCT were retrospectively collated, and the microscopic morphology of maxillofacial GCT was analyzed. The expression of S-100, neuron-specific enolase (NSE), SOX-10, CD68, actin, desmin, and Ki-67 in GCT was detected by immunohistochemical staining. The cases were observed in the follow-ups after clinical treatment.@*RESULTS@#All seven GCT tumors lacked envelopes and were poorly defined. Microscopically, the sizes of the tumor cells were large and appeared with inconspicuous cell membranes, forming a syncytium-like appearance. The cytoplasm was filled with characteristic eosinophilic granules. The immunohistochemical results showed that six cases were NSE-positive, five cases were S-100-positive, seven cases were CD68-positive, five cases were SOX-10-positive, one case was actin-positive, and seven cases were desmin-negative. The Ki-67 index did not exceed 5% in all cases. In the follow-up sessions, none of the six cases presented a recurrence.@*CONCLUSIONS@#Maxillofacial GCT has a characteristic histological structure. Immunohistochemical S-100, CD68, and other indicators can assist in diagnosis, and the prognosis is good after clinical resection.
Key words
Full text:
1
Index:
WPRIM
Main subject:
S100 Proteins
/
Retrospective Studies
/
Actins
/
Granular Cell Tumor
/
Ki-67 Antigen
/
Desmin
Limits:
Humans
Language:
En
Journal:
West China Journal of Stomatology
Year:
2023
Type:
Article