A new cytotoxic flavone from Cassia nomame / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4203-4206, 2019.
Article
in Zh
| WPRIM
| ID: wpr-1008280
Responsible library:
WPRO
ABSTRACT
A new flavone( 1) has been isolated from the whole plant of Cassia nomame by using various chromatographic techniques,including silica gel,Sephadex,MCI-gel resin,and RP-HPLC,and its structure was determined as 8,4'-dimethoxy-7-( 2-oxopropyl)-flavone based on spectroscopic data. The biological activity test showed that this compound displayed potent cytotoxicity against NB4,SH-SY5 Y,PC3,A549 and MCF-7 cell lines with IC50 values 2. 2,1. 8,3. 4,4. 5 and 1. 6 μmol·L-1,respectively.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Cassia
/
Chromatography, High Pressure Liquid
/
Senna Plant
/
Flavones
/
MCF-7 Cells
Limits:
Humans
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2019
Type:
Article