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Research Advance of Chinese Medicine in Treating Atherosclerosis: Focus on Lipoprotein-Associated Phospholipase A2 / 中国结合医学杂志
Chinese journal of integrative medicine ; (12): 277-288, 2024.
Article in English | WPRIM | ID: wpr-1010331
ABSTRACT
As a serious cardiovascular disease, atherosclerosis (AS) causes chronic inflammation and oxidative stress in the body and poses a threat to human health. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 (PLA2) family, and its elevated levels have been shown to contribute to AS. Lp-PLA2 is closely related to a variety of lipoproteins, and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine (oxPC) to produce lysophosphatidylcholine (lysoPC). Moreover, macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque instability. This paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biomarkers / 1-Alkyl-2-acetylglycerophosphocholine Esterase / Atherosclerosis / Plaque, Atherosclerotic / Lipoproteins / Medicine, Chinese Traditional Limits: Humans Language: English Journal: Chinese journal of integrative medicine Year: 2024 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biomarkers / 1-Alkyl-2-acetylglycerophosphocholine Esterase / Atherosclerosis / Plaque, Atherosclerotic / Lipoproteins / Medicine, Chinese Traditional Limits: Humans Language: English Journal: Chinese journal of integrative medicine Year: 2024 Type: Article