Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy
Acta Pharmaceutica Sinica B
; (6): 4688-4714, 2023.
Article
in En
| WPRIM
| ID: wpr-1011211
Responsible library:
WPRO
ABSTRACT
Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 kinase) complex, thus controlling autophagy induction and other cellular trafficking events. Notably, there is mounting evidence establishing the implications of Beclin-1 in diverse tumorigenesis processes, including tumor suppression and progression as well as resistance to cancer therapeutics and CSC (cancer stem-like cell) maintenance. More importantly, Beclin-1 has been confirmed as a potential target for the treatment of multiple cancers. In this review, we provide a comprehensive survey of the structure, functions, and regulations of Beclin-1, and we discuss recent advances in understanding the controversial roles of Beclin-1 in oncology. Moreover, we focus on summarizing the targeted Beclin-1-regulating strategies in cancer therapy, providing novel insights into a promising strategy for regulating Beclin-1 to improve cancer therapeutics in the future.
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WPRIM
Language:
En
Journal:
Acta Pharmaceutica Sinica B
Year:
2023
Type:
Article