Eplerenone protects contralateral kidney tissue from obstruction in pregnant rats with chronic kidney disease

Chang XU; Wen-Ping ZHOU; Jie-Qi NIU; Hong-Shuang WANG; Meng-Juan ZHANG; Jia-Zhi LIU; Chang XU; Qing-You XU; Wen-Ping ZHOU; Jie-Qi NIU; Yun-Zhao XIONG; Yan ZHONG; Zheng WANG; Qing-You XU; Yun-Zhao XIONG; Yan ZHONG; Xiang-Ting WANG; Zheng WANG; Hong-Shuang WANG; Meng-Juan ZHANG; Jia-Zhi LIU

Eplerenone protects contralateral kidney tissue from obstruction in pregnant rats with chronic kidney disease / 中国药理学通报

Chang XU; Wen-Ping ZHOU; Jie-Qi NIU; Hong-Shuang WANG; Meng-Juan ZHANG; Jia-Zhi LIU; Chang XU; Qing-You XU; Wen-Ping ZHOU; Jie-Qi NIU; Yun-Zhao XIONG; Yan ZHONG; Zheng WANG; Qing-You XU; Yun-Zhao XIONG; Yan ZHONG; Xiang-Ting WANG; Zheng WANG; Hong-Shuang WANG; Meng-Juan ZHANG; Jia-Zhi LIU.

Chinese Pharmacological Bulletin ; (12): 1534-1540, 2023.

Article in Zh | WPRIM | ID: wpr-1013744

Responsible library: WPRO

ABSTRACT

ABSTRACT

Aim To study the protective effect of eplerenone on the contralateral kidney in pregnant rats with chronic kidney disease (CKD) and its mechanism. Methods Female Wistar rats were randomly divided into sham-operation group, sham-operation pregnancy group, model group and eplerenone group. The rats in the model group and eplenone group had ligation unilateral ureter, and the rats in the eplenone group were treated with 100 mg • kg

Key words

chronic kidney disease; eplerenone; lymphangiogenesis; obstruction of contralateral kidney; pregnancy; renal fibrosis; SGK-1/N F - Κ B signaling pathway

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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2023 Type: Article

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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2023 Type: Article