Research progress of Gasdermin D / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 817-822, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1013912
Responsible library:
WPRO
ABSTRACT
Pyroptosis is a novel process of programmed inflammatory necrosis, which is closely related to microbial infections and autoimmune diseases. In recent years it has been proved that Gasdermin D is an executive protein of pyroptosis. Cleaved Gasdermin D leads to the formation of pores in cell membrane to induce pyroptosis, and the release of inflammatory factors such as IL-1β and IL-18 aggravates the occurrence of inflammatory responses. With the deepening of Gasdermin D research, it is gradually clear its protein structure and activation sites, which has other activation pathways apart from inducing inflammasome activation. Activation of Gasdermin D does not necessarily mean cell death, even if it could induce the formation of pores in cell membrane and regulation of inflammatory cytokine secretion. These findings offer insight into Gasdermin D function and change our understanding of pyroptosis and programmed necrosis. The recent progress of Gasdermin D is highlighted in this review.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2023
Type:
Article