Effects of betulinic acid on epithelial-mesenchymal transition of human gastric cancer MKN-45 cells / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1438-1443, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1013954
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ABSTRACT
Aim To observe the effect of betulinic acid (BA) on the migration and invasion of human gastric cancer MKN-45 cells induced by transforming growth factor-pi (TGF-β1), and to explore the effect of BA on epithelial-mesenchymal transition (EMT) and the potential mechanism. Methods The MKN-45 cells were cultivated in vitro, and the effects of different concentrations of BA on the proliferation of MKN-45 cells at 24, 48 and 72 h were detected using CCK-8 method. The effects of BA (5, 10, 20 jjunol • L) and TGF-01 inhibitor LY2109761 (10
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Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2023
Type:
Article