Study on difference of transitional components in blood of Radix Aconiti processed by Hezi decoction / 中国药理学通报

ABSTRACT

Aim To analyze the differences of transitional components in serum before and after processing of Radix Aconiti, and to reveal the processing mechanism of Radix Aconiti from the perspective of serum pharmacochemistry. Methods Radix Aconiti prepared by processing Radix Aconiti and Hezi decoction was subdivided into 0.5% sodium carboxymethylcellulose suspension, and then the drug containing serum was prepared. The UPLC characteristic maps of serum in blank group, Radix Aconiti group and Radix Aconiti prepared by processing Radix Aconiti Decoction were established, analyzed and compared, and the differences of serum migration components before and after processing were determined. Results A total of 11 blood transitional components were detected and 6 prototype components were identified in the drug containing plasma samples of raw Aconitum group. A total of 14 blood transitional components were detected and 8 prototype components were identified in the drug containing plasma samples of processed Aconitum group of Hezi decoction. Conclusions There are significant differences in serum transitional components before and after processing, which provides an experimental basis for the further study of the processing mechanism of Herba Aconiti in Hezi Decoction in the future.