The total terpenoids of Celastrus aggravate DNA damage and induce apoptosis of gastric cancer cells by inhibiting Chk1

Zhuang-Zhuang JIANG; Yue YOU; Yang ZHAO; Li TAO; Yan-Qing LIU

The total terpenoids of Celastrus aggravate DNA damage and induce apoptosis of gastric cancer cells by inhibiting Chk1 / 中国药理学通报

Zhuang-Zhuang JIANG; Yue YOU; Yang ZHAO; Li TAO; Yan-Qing LIU.

Chinese Pharmacological Bulletin ; (12): 417-423, 2021.

Article in Zh | WPRIM | ID: wpr-1014352

Responsible library: WPRO

ABSTRACT

ABSTRACT

Aim To explore the inhibitory effect of the on gastric cancer cells from the perspective of DNA total terpenoids of Celastrus orbiculatus Thunb (TTC) damage response. Methods CCK-8 experiment was conducted to investigate the toxic effects of different concentrations

Key words

cell apoptosis; checkpoint kinase 1; DNA damage response; DNA double strand break; gastric canc¬er cells; total terpenoids of Celastrus

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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2021 Type: Article

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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2021 Type: Article