Research progress of miRNAs in exosomes derived from bone-related cells regulating bone formation / 中国药理学通报

ABSTRACT

Exosome is a goblet-shaped extracellular vesicle with a lipid bilayer structure, and its diameter is about 30-150 nm. Exosomes participate in cell-to-cell communication by transporting proteins, miRNAs, and other biologically active factors, thereby affecting recipient cells. In recent years, a lot of studies have shown that exosomes derived from bone-related cells can not only mediate intercellular communication within the bone marrow microenvironment in a range of physiological conditions, but also contribute to the multiple pathological conditions in skeletal disorders. Here, we summarized the regulation of miR-NA in exosomes derived from bone-related cells on bone formation.