Sacubitril/valsartan reduces susceptibility of atrial fibrillation by reversing structural remodeling of atrial in spontaneously hypertensive rats

Qian LI; Xin LI; Lu-An LI; Hui-Shan ZHOU; De-Wei PENG; Chun-Yu DENG; Fang RAO; Shu-Lin WU; Qian LI; Xin LI; Lu-An LI; Hui-Shan ZHOU; De-Wei PENG; Meng-Zhen ZHANG; Zhao-Yu WANG; Su-Juan KUANG; Chun-Yu DENG; Fang RAO; Shu-Lin WU

Sacubitril/valsartan reduces susceptibility of atrial fibrillation by reversing structural remodeling of atrial in spontaneously hypertensive rats / 中国药理学通报

Qian LI; Xin LI; Lu-An LI; Hui-Shan ZHOU; De-Wei PENG; Chun-Yu DENG; Fang RAO; Shu-Lin WU; Qian LI; Xin LI; Lu-An LI; Hui-Shan ZHOU; De-Wei PENG; Meng-Zhen ZHANG; Zhao-Yu WANG; Su-Juan KUANG; Chun-Yu DENG; Fang RAO; Shu-Lin WU.

Chinese Pharmacological Bulletin ; (12): 631-637, 2021.

Article in Zh | WPRIM | ID: wpr-1014410

Responsible library: WPRO

ABSTRACT

ABSTRACT

Aim To observe the effects of sacubitril/valsartan (Sac/Val, LCZ696) on atrial remodeling and atrial fibrillation (AF) susceptibility in spontaneously hypertensive rats (SHR). Methods Twenty-four 7-week-old male SHR were randomly divided into SHR group, SHR + Val group (30 mg · kg

Key words

atrial fibrillation; fibrosis; renin-angiotensin system; sacubitril/valsartan; spontaneously hypertensive rats; valsartan

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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2021 Type: Article

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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Pharmacological Bulletin Year: 2021 Type: Article