Research progress and mechanism of mesenchymal stem cells in the treatment of autoimmune diseases / 中国临床药理学与治疗学

ABSTRACT

Mesenchymal stromal/stem cells (MSCs) are a type of pluripotent stem cells capable of differentiating into osteoblasts, chondrocytes, adipocytes, and cardiomyocytes. MSCs can be obtained from a variety of sources, including bone marrow, adipose tissue, dental pulp, The umbilical cord and the placenta, peripheral blood, skin, and synovial fluid. Studies at home and abroad have shown that MSCs have important research value and great application potential in the treatment of a variety of autoimmune diseases. MSCs have opened a new door for the medical community, and triggered an upsurge of research on MSCs transplantation for autoimmune disease trials. However, in view of the limitations of current MSCs, the safe application of MSCs in the treatment of autoimmune diseases still requires larger and more in-depth trial and clinical data support. In this paper, we will review the therapeutic effect of MSCs in autoimmune diseases and the possible mechanism of its effect.