Effect of chronic restraint stress on the phenotypic transition of hippocampal astrocytes and depression-like behavior in mice / 解剖学报
Acta Anatomica Sinica
; (6): 42-49, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1015245
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WPRO
ABSTRACT
Objective To explore the effect of chronic restraint stress (CRS) on the phenotypic transition of hippocampal astrocytes and depression-like behavior in mice. Methods Forty eight male C57BL/6 mice were randomly divided into control groups (control), model groups (CRS) and fluoxetine(FLX) drug intervention groups (CRS+FLX), 16 for each group. The mice of the CRS group were subjected to 3 weeks chronic restraint stress. The mice of CRS + FLX group were treated with fluoxetine by intraperitoneal injection 30 minutes before restraint stress from the day 8 to day 21.
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WPRIM
Language:
Zh
Journal:
Acta Anatomica Sinica
Year:
2023
Type:
Article