Progress in Research on Mechanosensitive Ion Channel Piezo1/2 in Digestive System Diseases / 胃肠病学
Chinese Journal of Gastroenterology
; (12): 560-563, 2020.
Article
in Zh
| WPRIM
| ID: wpr-1016326
Responsible library:
WPRO
ABSTRACT
Piezo proteins, including Piezo1, Piezo2, are non-selective mechanosensitive ion channels. They have similar biophysical characteristics, which can transform mechanical signals into biological electric signals. Studies have shown that Piezo proteins play important roles in mechanical-relevant physiological functions and pathophysiological changes of a variety of organs, including gastrointestinal tract. This article reviewed the relationship between Piezo1/2 proteins and digestive system diseases, and discussed the roles of Piezo1/2 under mechanical stress in the development of digestive system diseases, so as to provide a novel target in the study of pathogenesis and treatment of relevant digestive system diseases.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Gastroenterology
Year:
2020
Type:
Article