Research progress of cGAS-STING signaling pathway modulators in immunotherapy / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 15-25, 2024.
Article
in Zh
| WPRIM
| ID: wpr-1017106
Responsible library:
WPRO
ABSTRACT
@#Abstract: Upon monitoring cytoplasmic aberrant double-stranded DNA, cGAS-STING signaling pathway induces the expression of type I interferons and pro-inflammatory cytokines, which activates the host immune response and enhances anti-tumor immune response and resistance to pathogen infection. However, sustained activation of the cGAS-STING signaling pathway drives diseases such as autoimmune diseases, aging-associated inflammation, and neurodegenerative pathologies. Herein, we describe the mechanism by which cGAS-STING signaling pathway participates in regulating the development of various immune-related diseases, with a particular review of the research and development progress of STING agonists, cGAS inhibitors, and STING inhibitors, aiming to provide some theoretical reference for the future development of cGAS-STING modulators.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Journal of China Pharmaceutical University
Year:
2024
Type:
Article