Advances in viral infections and febrile seizures in children / 国际儿科学杂志

ABSTRACT

Febrile seizures are the most common cause of convulsions in children.It is believed that the pathogenesis of febrile seizures involves a variety of factors, with most domestic and international studies focusing on genetic susceptibility; in contrast, the role of environmental factors, especially viral infections, is a relatively neglected field.Children are at high risk for various viral infections, many of which are prone to cause hyperthermia and induce febrile seizures when the individual convulsive temperature threshold is exceeded; in addition, inflammatory cytokines produced during viral infections may cross the blood-brain barrier affecting nerve cells.Focusing on the clinical characteristics and pathogenesis of febrile seizures caused by various viral infections in children, such as human herpesvirus-6, respiratory viruses(influenza virus, respiratory syncytial virus, adenovirus, severe acute respiratory syndrome coronavirus 2), gastroenteritis-associated viruses(rotavirus, norovirus), enteroviruses, this review may help clinicians understand the role of different viral infections in febrile seizures.