Analysis of medication rule of TCM and signal pathway and molecular targets for chronic atrophic gastritis based on animal experiment literature / 国际中医中药杂志

ABSTRACT

Objective:To investigate the medication law of TCM and signaling pathway as well as molecular targets in the treatment of chronic atrophic gastritis (CAG).Methods:The literature on TCM treatment of CAG rats in the databases of CNKI, CBM, CQVIP, Wanfang Database, PubMed and Web of Science from January 1, 2010 to May 31, 2022 were retrieved. The literature was screened and evaluated based on inclusion and exclusion criteria. The information on the medicine composition, signaling pathways and molecular targets of formulas was collated and analyzed.Results:A total of 304 articles were included in this study, involving 118 prescriptions and 174 kinds of Chinese materia medica. The high-frequency drugs were Atractylodis Macrocephalae Rhizoma, Glycyrrhizae Radix et Rhizoma, Curcumae Rhizoma. The most common drug pair were Paeoniae Radix alba-Glycyrrhizae Radix et Rhizoma, Scleromitrion diffusum (Willd.) R. J. Wang-Curcumae Rhizoma、Atractylodis Macrocephalae Rhizoma-Poria. The association rule with high confidence were Coptidis Rhizoma-Codonopsis Radix-Pinelliae Rhizoma, Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma-Pinelliae Rhizoma, Codonopsis Radix-Hedyotidis Herba-Curcumae Rhizoma. A total of 16 signaling pathways were involved, including PI3K/Akt, hedgehog, Wnt and TLR4 signal pathways with high frequency. There were 198 molecular targets, mainly including inflammation immunity targets (IL-6, NF-κB, TNF-α), proliferation and apoptosis related targets (Bcl-2, PCNA, Bax), Oxidative damage molecules (SOD, MDA), gastric mucosal secretion markers (GAS, PG), and hypoxia or angiogenesis markers (HIF-1 ɑ, VEGF).Conclusion:This study summarizes the drug distribution law and action mechanism of prevention and treatment of CAG with TCM in the field of basic research, which provides the reference for understand the overview of basic research on CAG with TCM.