Research progress of glycolysis induced islet β cell dedifferentiation based on HIF-1α/PFKFB3 signaling pathway / 中国糖尿病杂志
Chinese Journal of Diabetes
; (12): 222-226, 2024.
Article
in Zh
| WPRIM
| ID: wpr-1025180
Responsible library:
WPRO
ABSTRACT
Islet β cell dedifferentiation is one of the important reasons leading to insulin secretion defect or insulin resistance in patients with type 2 diabetes mellitus(T2DM).HIF-1α/PFKFB3 signaling pathway is a newly discovered biological pathway related to T2DM,which is involved in the induction of islet β cells dedifferentiation by anaerobic glycolysis under high glucose environment.This article reviews the research progress of the role of HIF-1α/PFKFB3 signaling pathway in glycolysis induced islet β cell dedifferentiation.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Diabetes
Year:
2024
Type:
Article