Research progress of iron homeostasis and ferroptosis in acute kidney injury / 中国中西医结合急救杂志

ABSTRACT

Ferroptosis is a non-apoptotic form of cell death newly discovered in 2012.It is characterized by a lethal accumulation of iron-dependent reactive oxygen species and lipid hydroperoxides,resulting in mitochondrial morphological changes and phospholipid peroxidation damage of cell membrane.As a strong oxidizing agent in biological systems,iron overloaded,can directly cause acute kidney injury(AKI)through oxidative damage.Iron homeostasis disturbance and ferroptosis are directly involved in AKI caused by ischemia-reperfusion,drugs and rhabdomyolysis,etc.This article reviews the relevant evidence and the important mechanism of iron homeostasis and ferroptosis in AKI,and provides new ideas and new targets for further research and treatment of AKI.