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Research progress in histone acetylation in radiation-related DNA damage / 中华放射肿瘤学杂志
Article in Zh | WPRIM | ID: wpr-1027514
Responsible library: WPRO
ABSTRACT
Radiotherapy is a first-line treatment for a variety of malignant tumors by inducing DNA damage to kill tumor cells. However, tumor cells have different sensitivities to radiotherapy, ultimately leading to different therapeutic effects. Histone acetylation, regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC), is involved in the regulation of cell radiation sensitivity by influencing DNA damage repair. The main mechanisms are recruiting DNA repair related proteins and mediating chromatin dynamic changes. In this article, the role of histone acetylation modification in tumor radiotherapy was reviewed, aming to provide the basis for the radiotherapy sensitization strategy based on histone acetylation.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Radiation Oncology Year: 2024 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Radiation Oncology Year: 2024 Type: Article