Correlation between serum beta 2-microglobulin level and cerebral microbleeds in the elderly / 中华老年心脑血管病杂志
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
; (12): 55-58, 2024.
Article
in Zh
| WPRIM
| ID: wpr-1028089
Responsible library:
WPRO
ABSTRACT
Objective To explore the correlation between serum beta 2-microglobulin(B2M)level and cerebral microbleeds(CMB)in the elderly.Methods A retrospective analysis of 636 elderly patients with chronic diseases admitted to the Department of Neurology of our hospital from Janu-ary 2020 to November 2022 was made.On the second day after admission,venous blood samples were collected to detect the serum B2M level,and brain magnetic resonance susceptibility weigh-ted imaging was performed.Then these patients were assigned into CMB group(82 cases)and CMB-free group(554 cases).Binary logistic regression analysis was employed to identify the inde-pendent risk factors for CMB.Results Binary logistic regression analysis showed that serum B2M level was an independent risk factor for CMB in elderly patients(Model 1β=0.179,OR=1.196,95%CI1.017-1.407,P=0.031;Model 2β=0.215,OR=1.240,95%CI1.048-1.468,P=0.012)after adjusting confounding factors.ROC curve analysis indicated that the optimal cutoff value of serum B2M level in diagnosing CMB was 1.805 mg/L,with a sensitivity of 70.7%and a specificity of 52.5%,and an AUC value of 0.657(95%CI0.595-0.719,P<0.01).Conclusion The increment of serum B2M level is closely related to CMB in the elderly population,so the pro-tein can be used as one of indicators for prediction of CMB in the population.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
Year:
2024
Type:
Article