Research status and prospect of antibiotic resistance gene blaTEM in bacteria / 中华微生物学和免疫学杂志

ABSTRACT

β-lactam antibiotics are a class of antibiotics widely used in clinical treatment. The antibacterial mechanism of them is to inhibit the cell wall synthesis of bacteria. However, the widespread of β-lactam resistance genes among bacteria has posed a great challenge to the use of β-lactam antibiotics. One of the main genes encoding β-lactamase is blaTEM, and 243 subtypes of it have been identified to date. Studying blaTEM gene is of great significance in antibiotic resistance research. This review focused on the discovery, structure, promoter, distribution, spread, antibacterial mechanism and research status of blaTEM gene, hoping to provide reference for further research on the subtypes of β-lactam resistance genes in bacteria.