Clinical observation on mouse nerve growth factor in the prevention of dysfunction of cerebral trauma / 中华神经医学杂志

ABSTRACT

Objective To assess the clinical effects of mouse nerve growth factor (NGF) on prevention of cerebral trauma-induced dysfunction. Methods Thirty-three patients with cerebral trauma, admitted to our hospital from Mar. 2007 to Feb. 2009, were chosen as NGF-treated group and NGF were injected intramuscularly at a daily dose of 40 μg. Control group was composed of another 33 patients, whose consciousness and traumatic condition were comparable with those of NGF-treated group and conventional treatment was given. The data of Glasgow coma scale (GCS) and Karnofsky performance status (KPS) were analyzed in the 2 groups. Results The NGF-treated group showed significantly high CCS 14 d after treatment as compared with the control group (P<0.05). The KPS in the NGF-treated group was statistically higher than that in the control group 6 months after the treatment was ended (P<0.05). Conclusion NGF, one of the most important neurotrophin, is safe and effective in the prevention of postinjury dysfunction.