Effect of high frequency stimulation of subthalamic nucleus on discharge changes of globus pallidus nucleus in primate models of Parkinson's disease / 中华神经医学杂志

ABSTRACT

Objective To investigate the mechanism of high frequency stimulation (HFS) of subthalamic nucleus (STN) in treating primate models of Parkinson's disease (PD). Methods Two rhesus monkeys were injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into unilateral brain to induce the PD models; rhesus monkey models were implanted with glass recording electrodes and stimulating electrodes into the globus pallidus intemus (GPi) and STN, respectively. Extracellular recording was used to investigate the spikes and analyze the firing activity of GPi before and during STN-HFS. Results The spontaneous firing of GPi neurons on the normal side of PD monkeys was more regular than that on the abnormal side,and the frequency of firing was (44.38±13.66)spike/s and (50.57±15.53)spike/s respectively, without significant difference (P＞0.05). During STN-HFS, 4 neuronal activity changes existed, including incomplete inhibition, complete inhibition, increase of excitability and no change.STN-HFS could cause inhibition in most of the GPi neurons on both sides and the average inhibition rate on the abnormal side was 56.29％±29.66％,which was higher than that on the normal side(36.03％±35.25％),with statistically significant difference(P＜0.05).Conclusion HFS would do a certain extent suppression to the abnormal activity of STN neurons,resulting in a re-equilibrium in the neuronal activity of the basal ganglia motor circuit and the improvement of PD symptoms.