Effect of nonfunctioning pituitary adenoma apoplexy on growth rate of residual tumor after operation / 中华神经医学杂志

ABSTRACT

Objective To explore the effect of nonfunctioning pituitary adenoma (NFPA)apoplexy on growth rate of residual tumor after transsphenoidal operation.Methods The follow-up MR imaging data of 57 patients with NFPA who had residual tumors after transsphenoidal operation,admitted to our hospital from May 2005 to May 2015,were analyzed retrospectively.The tumor volume doubling time (TVDT) of residual tumors,rapid growth rate and apoplexy/tumor size ration were calculated.The relations of tumor rapid growth rate with existence of adenoma apoplexy,course of adenoma apoplexy and apoplexy/tumor size ration were compared.Results There were 30 patients with NFPA apoplexy and 27 without adenoma apoplexy.Postoperative follow-up indicated enlarged residual tumors in 49 patients,and shrank ones in 8 patients.The mean TVDT was (1305.82±1685.32) d.The rapid growth rate of residual tumors in NFPA apoplexy group (56.67％) was not significantly increased as compared with that in non-NFPA apoplexy group (66.67％,P＞0.05).The rapid growth rate of subacute NFPA apoplexy group (81.82％) was significantly higher than that of chronic NFPA apoplexy group (36.84％,P＜0.05).The rapid growth rate of group of apoplexy/tumor size ration less than 12％ (40％) was not significantly different as compared with that of rapid growth rate of group of apoplexy/tumor size ration more than 12％ (66.67％,P＞0.05).Conclusions Adenoma apoplexy is one of the factors that affect the growth rote of residual tumors ofNFPA after transsphenoidal operation.For patients with NFPA apoplexy in subacute or chronic phase,if their symptoms are mild,they can be followed up regularly.