Correlation between serum IL-1β, IL-16 levels and negative symptoms in different stages of schizophrenia / 安徽医科大学学报

ABSTRACT

Objective @#To explore the difference of serum inflammatory factors in patients with first episode schizo- phrenia , patients with relapse episode schizophrenia and healthy people , and the correlation between serum inflam- matory factors with negative symptoms in patients with schizophrenia , so as to provide reference for clinical inter- vention .@*Methods @#A total of 86 patients with first episode schizophrenia (first episode group) , 80 patients with re- lapse episode schizophrenia ( relapse episode group) and 82 healthy people ( control group) were included in the study. The difference of serum inflammatory factors among the three groups and the correlation between serum inflammatory factors with negative symptoms were analyzed .@*Results @#There were significant differences in serum interleukin (IL) -1βand IL-16 levels among the three groups (P < 0. 05) . The analysis and comparison between the two groups showed that the serum IL-1βin first episode group was significantly higher than that in relapse episode group and control group(P < 0. 05) , serum IL-16 in first episode group and relapse episode group was significantly higher than that in control group(P < 0. 05) . Serum IL-1βwas negatively correlated with PANSS general psycho- pathological scale factor score in first episode group( P < 0. 05) , and serum IL-16 was positively correlated with PANSS negative symptom scale factor score in relapse episode group( P < 0. 05) . IL-16 level might be an inde- pendent risk factor affecting the onset of first episode group and relapse episode group(P < 0. 05) . @*Conclusion@#There are differences in serum levels of IL-1βand IL-16 between patients with schizophrenia and healthy people . Serum IL-16 levels in patients with relapse episode schizophrenia are associated with negative symptoms . IL-16 lev- el may be an independent risk factor for schizophrenia.