Analysis of clinical features and diagnostic indicators of neurosyphilis patients with general paresis of insane / 中风与神经疾病杂志

ABSTRACT

@#Objective　To compare the clinical symptoms,laboratory and imaging results of neurosyphilis patients with and without general paresis of insane (GPI),and to analyze the clinical characteristics of patients with GPI and find the indexes that can help to realize early diagnosis.Method　A total of 104 patients with neurosyphilis were admitted from the First Affiliated Hospital of Naval Medical University from January 1,2010 to December 31,2021,including 59 patients with GPI and 45 patients without GPI.The demographic data,clinical manifestations,laboratory and imaging results were collected and compared.Result　There were significant differences of the cerebrospinal fluid protein,neutrophil count and neutrophil-lymphocyte ratio (NLR),the number of patients with limb weakness between these two groups.Cerebrospinal fluid protein≥755 mg/L、NLR ≥ 2.82 and absence of limb weakness were independent risk factors of GPI,and the binary logistic regression model including the risk factors can predict GPI.Conclusion　Neurosyphilis patients with GPI often show cognitive decline or/and psychiatric symptoms.NLR≥2.8,cerebrospinal fluid protein≥755 mg/L and clinical symptoms without limb weakness are predictors of GPI.When clinicians find neurosyphilis patients present with such characters,It is suggested to assess their cognitive function and mental symptoms and carry out intervention early,which is helpful to slow down or even reverse the occurrence of cognitive disability in patients with neurosyphilis.