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Spontaneous Regression of a Large Vestibular Schwannoma: Is Nonoperative Management Reasonable?
Article in En | WPRIM | ID: wpr-1042274
Responsible library: WPRO
ABSTRACT
Vestibular schwannomas (VSs) are the most common cerebellopontine tumors. The natural history of smaller-sized VSs (30 mm) have not been extensively studied, mainly because of their rarity. As such, most patients are conventionally offered surgery which carries a significant risk of neurological morbidity. Here, we report a case of a giant VS (>40 mm) in a 30-year-old man who regressed spontaneously. He was lost to follow-up for 18 years and, upon re-presentation, the symptomatology drastically improved and repeat imaging demonstrated a marked reduction in tumor size. Referring to similar cases in other studies, we postulate that most large and giant VSs undergo a phase of growth and stasis, followed by regression due to shifts in the balance between tumorigenic and regressive factors. Taken together with emerging molecular data, further studies are required to better understand the history of large and giant VSs to shape more personalized treatment options. This potentially includes non-operative management as a tenable option.
Full text: 1 Index: WPRIM Language: En Journal: Brain Tumor Research and Treatment Year: 2024 Type: Article
Full text: 1 Index: WPRIM Language: En Journal: Brain Tumor Research and Treatment Year: 2024 Type: Article