Periodic dynamic observation and analysis of cellular and humoral immunity indexes of adults infected with Omicron BA.1 / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 2117-2121, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1045986
Responsible library:
WPRO
ABSTRACT
Objective:
To analyze the immunological characteristics and antibody changes of patients infected with the Omicron BA.1 and evaluate the possibility of secondary infection.Methods:
A total of 104 patients infected with Omicron BA.1 in the Jinnan District of Tianjin from January 8 to February 2, 2022, were included in the study. The control group and case group were matched 1∶1 based on age, sex and vaccination status. Serum was collected from the case group and control group at 3, 6 and 9 months after infection. The serum levels of interleukin4 (IL-4), IL-5 and interferon-gamma (IFN-γ), as well as the positive rates of IgG, IgG1 and IgG2, were detected by ELISA.Results:
The highest concentration of IFN-γ in the case group at 6 months after infection was 145.4 pg/ml, followed by a decrease in concentration. The concentrations of IL-4 and IL-5 began to decrease at 6 months after infection (all P<0.001). There was no significant difference in the IgG2 positive rate between the case group and the control group at 6 months after BA.1 infection. However, at 9 months, there was a significant decrease compared to the control group (P=0.003). The ratio of IFN-γ/IL4 at 3 months after infection in the case group was lower than that in the control group (P<0.001). There was no significant difference in the ratio between the case group and the control group at 9 months after infection.Conclusion:
The cellular immune function has been impaired at 3 months after infection with BA.1, and the specific cellular immune and humoral immune functions decrease significantly after 6 months, and the risk of secondary infection increases.
Full text:
1
Index:
WPRIM
Main subject:
Immunoglobulin G
/
Interleukin-4
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Interleukin-5
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Interferon-gamma
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Immunity, Humoral
/
Coinfection
Limits:
Adult
/
Humans
Language:
Zh
Journal:
Chinese Journal of Preventive Medicine
Year:
2023
Type:
Article