Association between different treatment timings and adverse neonatal outcomes in pregnant women with syphilis during pregnancy / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 1782-1787, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1046261
Responsible library:
WPRO
ABSTRACT
Objective:
To analyze the association between different treatment timings and adverse neonatal outcomes (premature birth, death, congenital syphilis) in syphilis-infected pregnant women.Methods:
The National Management Information System for Prevention of HIV, Syphilis and HBV Mother-to-Child Transmission was used to collect information on the detection and treatment of syphilis-infected pregnant women and their newborns in Guangdong Province from October 2011 to December 2021. According to the gestational weeks of syphilis-infected pregnant women receiving penicillin treatment for the first time, they were divided into four groups treatment in the first trimester, treatment in the second trimester, treatment in the third trimester, and no treatment during pregnancy. Multivariate logistic regression was used to analyze the association between different treatment timings and adverse neonatal outcomes in syphilis-infected pregnant women.Results:
A total of 22 483 syphilis-infected pregnant women were included. The number of pregnant women who started treatment in the first trimester, second trimester, and third trimester and did not receive treatment during pregnancy were 4 549 (20.23%), 8 719 (38.78%), 2 235 (9.94%) and 6 980 (31.05%), respectively. Compared with pregnant women who started treatment in the first trimester, pregnant women who did not receive anti-syphilis treatment during pregnancy had increased risks of neonatal preterm birth (OR=1.42, 95%CI 1.24-1.62), death (OR=4.27, 95%CI 1.64-14.69) and congenital syphilis (OR=12.26, 95%CI 6.35-27.45). At the same time, the risk of congenital syphilis in the newborns of pregnant women who started anti-syphilis treatment in the second trimester (OR=2.68, 95%CI 1.34-6.16) and third trimester (OR=6.27, 95%CI 2.99-14.80) also increased.Conclusion:
Early initiation of anti-syphilis treatment during pregnancy in patients with syphilis can improve neonatal outcomes.
Full text:
1
Index:
WPRIM
Main subject:
Pregnancy Complications, Infectious
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Syphilis, Congenital
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Syphilis
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Infectious Disease Transmission, Vertical
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Pregnant Women
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Premature Birth
Limits:
Female
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Humans
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Newborn
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Pregnancy
Language:
Zh
Journal:
Chinese Journal of Preventive Medicine
Year:
2023
Type:
Article