Prevalence of Reduced Kidney Function by Estimated Glomerular Filtration Rate Using an Equation Based on Creatinine and Cystatin C in Metabolic Syndrome and Its Components in Korean Adults
Endocrinology and Metabolism
;
: 446-453, 2016.
Article
in English
| WPRIM
| ID: wpr-105267
ABSTRACT
BACKGROUND:
It is known that metabolic syndrome (MetS) is associated with chronic kidney disease. We evaluated and compared the prevalence of reduced kidney function in MetS and its components by estimated glomerular filtration rate (eGFR) using an equation based on creatinine (eGFRcr), cystatin C (eGFRcys), and combined creatinine-cystatin C (eGFRcr-cys) in Korean adults.METHODS:
We analyzed data from 3,649 adults who participated in a comprehensive health examination.RESULTS:
Mean values of eGFRcys were higher compared with mean values of eGFRcr (96.1±18.2 mL/min/1.73 m² vs. 91.2±13.6 mL/min/1.73 m²) in total subjects. The prevalence of reduced kidney function increased with age (9.6% for eGFRcys vs. 5.8% for eGFRcr-cys vs. 4.9% for eGFRcr, in subjects aged ≥60 years), and significantly increased with MetS, abdominal obesity, hypertension, high triglyceride, low high density lipoprotein (HDL), and high insulin resistance. The prevalence of MetS, abdominal obesity, hypertension, high insulin resistance, low HDL, and hepatic steatosis was significantly increased in subjects with reduced kidney function. This increased prevalence and the odds ratio of reduced kidney function for prevalence of MetS was highest for eGFRcys, followed by those of eGFRcr-cys, and eGFRcr.CONCLUSION:
The prevalence of reduced kidney function by eGFR was significantly increased in subjects with MetS and its related components. eGFRcys and eGFRcr-cys were superior to eGFRcr in detecting reduced kidney function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triglycerides
/
Insulin Resistance
/
Odds Ratio
/
Prevalence
/
Creatinine
/
Renal Insufficiency, Chronic
/
Cystatin C
/
Obesity, Abdominal
/
Glomerular Filtration Rate
/
Hypertension
Type of study:
Etiology study
/
Prevalence study
/
Risk factors
Limits:
Adult
/
Humans
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS