Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
The Korean Journal of Internal Medicine
; : 176-182, 2014.
Article
in En
| WPRIM
| ID: wpr-105995
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN).METHODS:
Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups.RESULTS:
On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis.CONCLUSIONS:
Our results suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis.Key words
Full text:
1
Index:
WPRIM
Main subject:
Atrophy
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Biopsy
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Fibrosis
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Immunohistochemistry
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Urokinase-Type Plasminogen Activator
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Biomarkers
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Plasminogen Activator Inhibitor 1
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Podocytes
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Receptors, Urokinase Plasminogen Activator
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Glomerulonephritis, IGA
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
/
Male
Language:
En
Journal:
The Korean Journal of Internal Medicine
Year:
2014
Type:
Article