Locally delivered antioxidant gel as an adjunct to nonsurgical therapy improves measures of oxidative stress and periodontal disease
Journal of Periodontal & Implant Science
;
: 121-129, 2013.
Article
in English
| WPRIM
| ID: wpr-107346
ABSTRACT
PURPOSE:
The present study has two aims; firstly, it attempts to verify the presence of oxidative stress by estimating the reactive oxygen species (ROS) levels in periodontal pockets > or =5 mm as compared to controls. The second aim is to evaluate the effect of lycopene as a locally delivered antioxidant gel on periodontal health and on the gingival crevicular fluid (GCF) levels of 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative injury.METHODS:
Thirty-one subjects participated in this study. In the pretreatment phase, the ROS levels in pockets > or =5 mm were measured by flow cytometry. Three sites in each subject were randomly assigned into each of the following experimental groups sham group, only scaling and root planing (SRP) was done; placebo group, local delivery of placebo gel after SRP; and lycopene group, local delivery of lycopene gel after SRP. Clinical parameters included recording site-specific measures of GCF 8-OHdG, plaque, gingivitis, probing depth, and clinical attachment level.RESULTS:
The gel, when delivered to the sites with oxidative stress, was effective in increasing clinical attachment and in reducing gingival inflammation, probing depth, and 8-OHdG levels as compared to the placebo and sham sites.CONCLUSIONS:
From this trial conducted over a period of 6 months, it was found that locally delivered lycopene seems to be effective in reducing the measures of oxidative stress and periodontal disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontal Diseases
/
Periodontal Pocket
/
Periodontitis
/
Carotenoids
/
Salicylamides
/
Gingival Crevicular Fluid
/
Root Planing
/
Reactive Oxygen Species
/
Oxidative Stress
/
Deoxyguanosine
Type of study:
Controlled clinical trial
Language:
English
Journal:
Journal of Periodontal & Implant Science
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS