Infants with Suspected Asthma Presenting with Recurrent or Persistent Wheezing / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
; : 23-29, 2010.
Article
in Ko
| WPRIM
| ID: wpr-109328
Responsible library:
WPRO
ABSTRACT
PURPOSE: This study was designed to investigate the characteristics of infants with recurrent or persistent wheezing who present normal chest X-ray. METHODS: Nonfebrile infants with recurrent or persistent wheezing who revealed normal or only peribronchial infiltration on chest X-rays were enrolled. All infants divided into 2 groups by CT findings: The bronchiolitis or asthma group (hyperinflation or peribronchial wall thickening) and the aspiration pneumonia group (air space consolidation). RESULTS: The subjects were 30 infants (26 males and 4 females). Their mean age was 6.5+/-3.51 months. CT findings revealed no congenital abnormalities of the airways. There were 22 patients (73.3%) in the bronchiolitis or asthma group and 8 patients (26.3%) in the aspiration pneumonia group. There was no difference in the levels of total IgE and serum eosinophil cationic proteins between the 2 groups (33.9+/-36.78 vs. 39.03+/-39.98/30.87+/-34.73 vs. 48.85+/-44.59, P>0.05). However, the concentration of peripheral eosinophils was significantly higher in the bronchiolitis or asthma group than that of the aspiration pneumonia group (272+/-191.03 vs. 92.25+/-79.33, P=0.012). The results of 24-hr pH monitoring did not show any difference between the 2 groups. During follow-up, 9 of the 20 in the bronchiolitis or asthma group and 4 of the 8 patients in the aspiration pneumonia group were diagnosed with infantile asthma. CONCLUSION: Aspiration pneumonia should be considered in infants presenting with recurrent or persistent wheezing who show normal X-ray without elevated levels of peripheral eosinophils.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pneumonia, Aspiration
/
Asthma
/
Congenital Abnormalities
/
Thorax
/
Immunoglobulin E
/
Bronchiolitis
/
Respiratory Sounds
/
Follow-Up Studies
/
Eosinophil Cationic Protein
/
Eosinophils
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
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Infant
/
Male
Language:
Ko
Journal:
Pediatric Allergy and Respiratory Disease
Year:
2010
Type:
Article