NF-kappa B activation following optic nerve transection
Korean Journal of Ophthalmology
; : 19-24, 1998.
Article
in En
| WPRIM
| ID: wpr-10934
Responsible library:
WPRO
ABSTRACT
In order to elucidate in vivo neuronal cell death in the retina, and involvement of NF-kappa B in this process, we studied the degeneration of retinal ganglion cells (RGCs) and the activation of NF-kappa B after transection of the optic nerve of adult rat at 5 mm from the eyeball. The morphology of dying ganglion cells in the retinal ganglion cell layer was observed by light and electron microscopy, the activation of NF-kappa B was investigated immunohistochemically. Seven and 14 days post-axotomy, dying cells contained pyknotic nuclei. The death of retinal ganglion cells involved apoptosis, activation of NF-kappa B (p50 and p65) was prominent in a time dependent manner. We observed axotomy-induced NF-kappa B activation, which may mediate apoptosis of retinal ganglion cells.
Full text:
1
Index:
WPRIM
Main subject:
Optic Nerve
/
Retinal Ganglion Cells
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Immunohistochemistry
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Microscopy, Electron
/
NF-kappa B
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Rats, Sprague-Dawley
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Apoptosis
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Axotomy
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Animals
Limits:
Animals
Language:
En
Journal:
Korean Journal of Ophthalmology
Year:
1998
Type:
Article