Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios
Yonsei Medical Journal
;
: 304-306, 2009.
Article
in English
| WPRIM
| ID: wpr-109386
ABSTRACT
This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit beta3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 +/- 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 +/- 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pedigree
/
Autistic Disorder
/
Receptors, GABA-A
/
Microsatellite Repeats
/
Genetic Predisposition to Disease
/
Asian People
/
Korea
Type of study:
Observational study
Limits:
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS