Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis
Journal of Veterinary Science
;
: 167-179, 2001.
Article
in English
| WPRIM
| ID: wpr-109438
ABSTRACT
Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice, Pim-1 kinase is involved in the control of cell growth, differentiation and apoptosis. Expression of Pim-1 kinase can be stimulated by a variety of growth factors and regulated at four different levels transcriptional, post-transcriptional, translational and post-translational. Several signal transduction pathways may be associated with the regulation of Pim-1's expression; accumulating data support that the expression of Pim-1 protein is mediated through activation of JAK/STATs. Recent studies of Pim family kinases indicate that Pim-1 kinase plays important roles outside of the hematopoietic system as well.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Gene Expression Regulation, Enzymologic
/
Cell Differentiation
/
Cell Division
/
Cell Transformation, Neoplastic
/
Proto-Oncogene Proteins
/
Protein Serine-Threonine Kinases
/
Apoptosis
/
Proto-Oncogene Proteins c-pim-1
/
Lymphoma
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Veterinary Science
Year:
2001
Type:
Article
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