Low molecular-weight heparin for thromboprophylaxis in patients undergoing gastric cancer surgery: an experience from one Korean institute
Annals of Surgical Treatment and Research
; : 22-27, 2014.
Article
in En
| WPRIM
| ID: wpr-111667
Responsible library:
WPRO
ABSTRACT
PURPOSE: This study evaluated the efficacy for preventing venous thromboembolism (VTE) and adverse effects of low-molecular-weight heparin (LMWH) in order to launch a prospective clinical trial in Korea. METHODS: We reviewed the medical records of 108 consecutive patients who underwent gastric cancer surgery. These patients were divided into 2 groups according to the type of thromboprophylaxis: group A, LMWH combined with intermittent pneumatic compression (IPC); group B, IPC alone. The postoperative outcomes of the two groups were compared. RESULTS: Symptomatic VTE was observed in only 1 patient (0.9%) from group B. Postoperative bleeding was more common in group A than in group B (10.9% vs. 7.5%), although the difference was not significant (P = 0.055). Most bleeding episodes were minor and managed conservatively without intervention. Only a high body mass index was associated with a significantly increased risk of postoperative bleeding (odds ratio, 1.45; 95% confidence interval, 1.12-2.43; P = 0.051). CONCLUSION: A 40 mg of enoxaparin sodium is a safe and feasible dose for prevention of VTE. With the results of this study, we are planning a prospective randomized clinical trial to investigate the clinical efficacy of LMWH thromboprophylaxis in gastric cancer patients in Korea.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Sodium
/
Stomach Neoplasms
/
Thromboembolism
/
Heparin
/
Body Mass Index
/
Medical Records
/
Prospective Studies
/
Enoxaparin
/
Heparin, Low-Molecular-Weight
/
Venous Thromboembolism
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Annals of Surgical Treatment and Research
Year:
2014
Type:
Article