Predictive Characteristics of Malignant Pheochromocytoma
Korean Journal of Urology
;
: 241-246, 2011.
Article
in English
| WPRIM
| ID: wpr-111798
ABSTRACT
PURPOSE:
The prognosis of patients with malignant pheochromocytoma is poor, but the predictive factors are not well understood. We aimed to identify the clinical characteristics predictive of malignancy after initial surgical removal in patients with pheochromocytoma. MATERIALS ANDMETHODS:
We retrospectively reviewed the records of 152 patients diagnosed with pheochromocytoma, including 5 (3.3%) with metastasis at the time of the initial surgical excision and 12 (7.9%) who developed metastasis during follow-up. To determine the factors predictive of malignancy, we compared clinical, radiographical, and urinary chemical findings between patients with benign and malignant disease. Mean follow-up was 41.5 months (range, 0.9-298 months) after surgery.RESULTS:
Malignant tumors were significantly larger than benign tumors (11.1+/-4.0 cm vs. 6.2+/-3.4 cm, p5.5 cm; 90.6% vs. 81.2%, p=0.025) and higher 24-hour secretion of vanillylmandelic acid (>2.1 vs. 5.5 cm) and minimally elevated 24-hour urinary vanillylmandelic acid (< or =2.1 mg/day/cm) were significantly associated with a higher probability of a malignant pheochromocytoma portending a lower metastasis-free survival and mandating more rigorous follow-up after surgery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pheochromocytoma
/
Prognosis
/
Vanilmandelic Acid
/
Catecholamines
/
Epinephrine
/
Norepinephrine
/
Survival Rate
/
Retrospective Studies
/
Follow-Up Studies
/
Adrenal Gland Neoplasms
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Urology
Year:
2011
Type:
Article
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