Angiostatin Works as Immune Modulatory Molecules via Inhibition of Neutrophil Activation and Migration
Journal of Bacteriology and Virology
; : 115-119, 2014.
Article
in Ko
| WPRIM
| ID: wpr-112737
Responsible library:
WPRO
ABSTRACT
Angiostatin is derived from enzymatic degradation of plasminogen and it has endogenous anti-angiogenic properties. Although tumor cells, macrophages, platelets, and neutrophils generate high amount of angiostatin, its expression is increased in inflammatory conditions. Moreover, angiostatin binds to integrin alpha(v)beta(3), ATP synthase, and angiomotin, which expressed on neutrophils. Activated neutrophils are essential to innate immune response, but also cause tissue damage through production of reactive oxygen species (ROS) and increase lifespan. In this article, it suggests several mechanism of angiostatin as immune regulator for neutrophils in inflammatory conditions; complex with integrin alpha(v)beta(3) and F(1)F(0) ATP synthase on lipid raft, attenuate polarization, and ROS production. These data provide possible exploit of double-edged role of neutrophils in acute inflammatory pathologies to preserve beneficial effect and minimize tissue damage.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Plasminogen
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Adenosine Triphosphate
/
Reactive Oxygen Species
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Apoptosis
/
Neutrophil Activation
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Integrin alphaVbeta3
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Angiostatins
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Immunity, Innate
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Macrophages
Language:
Ko
Journal:
Journal of Bacteriology and Virology
Year:
2014
Type:
Article