Calcium Uptake and Release through Sarcoplasmic Reticulum in the Inferior Oblique Muscles of Patients with Inferior Oblique Overaction
Yonsei Medical Journal
; : 207-213, 2006.
Article
in En
| WPRIM
| ID: wpr-113989
Responsible library:
WPRO
ABSTRACT
We characterized and compared the characteristics of Ca2+ movements through the sarcoplasmic reticulum of inferior oblique muscles in the various conditions including primary inferior oblique overaction (IOOA), secondary IOOA, and controls, so as to further understand the pathogenesis of primary IOOA. Of 15 specimens obtained through inferior oblique myectomy, six were from primary IOOA, 6 from secondary IOOA, and the remaining 3 were controls from enucleated eyes. Ryanodine binding assays were performed, and Ca2+ uptake rates, calsequestrins and SERCA levels were determined. Ryanodine bindings and sarcoplasmic reticulum Ca2+ uptake rates were significantly decreased in primary IOOA (p < 0.05). Western blot analysis conducted to quantify calsequestrins and SERCA, found no significant difference between primary IOOA, secondary IOOA, and the controls. Increased intracellular Ca2+ concentration due to reduced sarcoplasmic reticulum Ca2+ uptake may play a role in primary IOOA.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Oxalates
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Ryanodine
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Sarcoplasmic Reticulum
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Calsequestrin
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Ocular Motility Disorders
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Blotting, Western
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Calcium
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Models, Statistical
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Calcium-Transporting ATPases
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Ryanodine Receptor Calcium Release Channel
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Male
Language:
En
Journal:
Yonsei Medical Journal
Year:
2006
Type:
Article