Propofol has delayed myocardial protective effects after a regional ischemia/reperfusion injury in an in vivo rat heart model / 대한마취과학회지
Korean Journal of Anesthesiology
; : 378-382, 2010.
Article
in En
| WPRIM
| ID: wpr-11415
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
It is well known that propofol protects myocardium against myocardial ischemia/reperfusion injury in the rat heart model. The aim of this study was to investigate whether propofol provides a protective effect against a regional myocardial ischemia/reperfusion injury in an in vivo rat heart model after 48 h of reperfusion.METHODS:
Rats were subjected to 25 min of left coronary artery occlusion followed by 48 h of reperfusion. The sham group received profopol without ischemic injury. The control group received normal saline with ischemia/reperfusion injury. The propofol group received profopol with ischemia/reperfusion injury. The intralipid group received intralipid with ischemia/reperfusion injury. A microcatheter was advanced into the left ventricle and the hemodynamic function was evaluated. The infarct size was determined by triphenyltetrazolium staining. The serum level of cardiac troponin-I (cTn-I) was determined by ELISA (enzyme-linked immunosorbent assay).RESULTS:
Propofol demonstrated protective effects on hemodynamic function and infarct size reduction. In the propofol group, the +dP/dt(max) (P = 0.002) was significantly improved compared to the control group. The infarct size was 49.8% of the area at risk in the control group, and was reduced markedly by administration of propofol to 32.6% in the propofol group (P = 0.014). The ischemia/reperfusion-induced serum level of cTn-I was reduced by propofol infusion during the peri-ischemic period (P = 0.0001).CONCLUSIONS:
Propofol, which infused at clinically relevant concentration during the peri-ischemic period, has delayed myocardial protective effect after regional myocardial ischemia/reperfusion injury in an in vivo rat heart model after 48 h of reperfusion.Key words
Full text:
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Index:
WPRIM
Main subject:
Phospholipids
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Tetrazolium Salts
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Soybean Oil
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Enzyme-Linked Immunosorbent Assay
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Reperfusion
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Propofol
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Salicylamides
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Troponin I
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Coronary Vessels
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Emulsions
Limits:
Animals
Language:
En
Journal:
Korean Journal of Anesthesiology
Year:
2010
Type:
Article