Comparative Analysis of Serum Proteomes of Moyamoya Disease and Normal Controls
Journal of Korean Neurosurgical Society
; : 8-13, 2010.
Article
in En
| WPRIM
| ID: wpr-114545
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
The etiology and pathogenesis of moyamoya disease remain unclear. Furthermore, the definitive diagnostic protein-biomarkers for moyamoya disease are still unknown. The present study analyzed serum proteomes from normal controls and moyamoya patients to identify novel serological biomarkers for diagnosing moyamoya disease.METHODS:
We compared the two-dimensional electrophoresis patterns of sera from moyamoya disease patients and normal controls and identified the differentially-expressed spots by matrix-assisted laser desorption/ionization-time-of flight mass spectrometry and electrospray ionization quadruple time-of-flight mass spectrometry.RESULTS:
We found and analyzed 22 differently-expressed proteomes. Two proteins were up-regulated. Twenty proteins were down-regulated. Complement C1 inhibitor protein and apolipoprotein C-III showed predominantly changed expressions (complement C1 inhibitor protein averaged a 7.23-fold expression in moyamoya patients as compared to controls, while apolipoprotein C-III averaged a 0.066-fold expression).CONCLUSION:
Although our study had a small sample size, our proteomic data provide serologic clue proteins for understanding moyamoya disease.Key words
Full text:
1
Index:
WPRIM
Main subject:
Mass Spectrometry
/
Biomarkers
/
Proteins
/
Sample Size
/
Proteome
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Electrophoresis
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Complement C1 Inhibitor Protein
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Apolipoprotein C-III
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Moyamoya Disease
Limits:
Humans
Language:
En
Journal:
Journal of Korean Neurosurgical Society
Year:
2010
Type:
Article