Interpretation of screening for congenital adrenal hyperplasia in preterm infants / 소아과
Korean Journal of Pediatrics
; : 616-621, 2008.
Article
in Ko
| WPRIM
| ID: wpr-115580
Responsible library:
WPRO
ABSTRACT
PURPOSE:
This study was undertaken to identify factors that influence 17-OHP levels in preterm infants and to suggest a reasonable follow-up schedule of screening for congenital adrenal hyperplasia (CAH) in preterm infants.METHODS:
The 17-OHP concentrations in filter paper blood spots of 427 preterm infants were obtained. The effects of gestational age (GA), systemic diseases, and antenatal dexamethasone on screening and follow-up 17-OHP values were investigated.RESULTS:
The screening 17-OHP values were markedly variable (range 0.1-143.3 ng/mL). The screening 17-OHP levels were negatively correlated with GA (r=-0.535, P or =20 ng/mL, the intervals until rescreening 17-OHP <10 ng/mL or serum 17-OHP <20 ng/mL were negatively correlated with GA (r=-0.541, P<0.01) and were prolonged in infants with bronchopulmonary dysplasia (P<0.01). None of the preterm infants were confirmatively diagnosed with CAH.CONCLUSION:
The 17-OHP values of preterm infants were influenced by GA, prenatal dexamethasone, and postnatal diseases. Because the 17-OHP vlues of preterm infants were markedly variable, a follow-up schedule should be developed considering both 17-OHP values and clinical status.Key words
Full text:
1
Index:
WPRIM
Main subject:
Appointments and Schedules
/
Bronchopulmonary Dysplasia
/
Infant, Premature
/
Dexamethasone
/
Mass Screening
/
Follow-Up Studies
/
Gestational Age
/
Neonatal Screening
/
Adrenal Hyperplasia, Congenital
/
Hypotension
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Humans
/
Infant
/
Newborn
Language:
Ko
Journal:
Korean Journal of Pediatrics
Year:
2008
Type:
Article