Vitamin D, and Kidney Disease
Electrolytes & Blood Pressure
;
: 1-6, 2011.
Article
in English
| WPRIM
| ID: wpr-121306
ABSTRACT
Mineral metabolism abnormalities, such as low 1,25-dihydroxyvitamin D (1,25(OH)2D) and elevated parathyroid hormone (PTH), are common at even higher glomerular filtration rate than previously described. Levels of 25-hydroxyvitamin D (25(OH)D) show an inverse correlation with those of intact PTH and phosphorus. Studies of the general population found much higher all-cause and cardiovascular (CV) mortality for patients with lower levels of vitamin D; this finding suggests that low 25(OH)D level is a risk factor and predictive of CV events in patients without chronic kidney disease (CKD). 25(OH)D/1,25(OH)2D becomes deficient with progression of CKD. Additionally, studies of dialysis patients have found an association of vitamin D deficiency with increased mortality. Restoration of the physiology of vitamin D receptor activation should be essential therapy for CKD patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parathyroid Hormone
/
Phosphorus
/
Vitamin D
/
Vitamin D Deficiency
/
Vitamins
/
Risk Factors
/
Receptors, Calcitriol
/
Dialysis
/
Renal Insufficiency, Chronic
/
Glomerular Filtration Rate
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Electrolytes & Blood Pressure
Year:
2011
Type:
Article
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