Distinctive clinical features of HPeV-3 infection in 2 neonates with a sepsis-like illness / 소아과
Korean Journal of Pediatrics
; : 308-311, 2016.
Article
in En
| WPRIM
| ID: wpr-125502
Responsible library:
WPRO
ABSTRACT
We report a human parechovirus-3 (HPeV-3) infection in 2 neonates who had prolonged fever (>5 days) with palmar-plantar erythema. This distinctive rash was observed 4–5 days after fever onset, just before defervescence. Elevated aspartate aminotransferase, lactate dehydrogenase, and ferritin levels were characteristic laboratory findings in the 2 cases, suggesting tissue damage caused by hypercytokinemia. Case 1 was treated with intravenous immunoglobulin, considering the possibility of severe systemic inflammatory responses. The initial ferritin level was 385 ng/mL (range, 0–400 ng/mL); however, the level increased to 2,581 ng/dL on day 5 after fever onset. Case 2 presented with milder clinical symptoms, and the patient recovered spontaneously. HPeV-3 was detected in cerebrospinal fluid and/or blood samples, but no other causative agents were detected. The findings from our cases, in accordance with recent studies, suggest that clinical features such as palmar-plantar erythema and/or hyperferritinemia might be indicators of HPeV-3 infection in neonates with sepsis-like illness. In clinical practice, where virology testing is not easily accessible, clinical features such as palmar-plantar erythema and/or hyperferritinemia might be helpful to diagnose HPeV-3 infection.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Aspartate Aminotransferases
/
Virology
/
Immunoglobulins
/
Cerebrospinal Fluid
/
Parechovirus
/
Erythema
/
Exanthema
/
Ferritins
/
Fever
/
L-Lactate Dehydrogenase
Limits:
Humans
/
Newborn
Language:
En
Journal:
Korean Journal of Pediatrics
Year:
2016
Type:
Article