What is fetal programming?: a lifetime health is under the control of in utero health
Obstetrics & Gynecology Science
; : 506-519, 2017.
Article
in En
| WPRIM
| ID: wpr-126359
Responsible library:
WPRO
ABSTRACT
The “Barker hypothesis” postulates that a number of organ structures and associated functions undergo programming during embryonic and fetal life, which determines the set point of physiological and metabolic responses that carry into adulthood. Hence, any stimulus or insult at a critical period of embryonic and fetal development can result in developmental adaptations that produce permanent structural, physiological and metabolic changes, thereby predisposing an individual to cardiovascular, metabolic and endocrine disease in adult life. This article will provide evidence linking these diseases to fetal undernutrition and an overview of previous studies in this area as well as current advances in understanding the mechanism and the role of the placenta in fetal programming.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Placenta
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Chronic Disease
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Critical Period, Psychological
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Malnutrition
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Fetal Nutrition Disorders
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Fetal Development
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Endocrine System Diseases
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Embryonic and Fetal Development
Limits:
Adult
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Humans
Language:
En
Journal:
Obstetrics & Gynecology Science
Year:
2017
Type:
Article