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Carcinoma ex Pleomorphic Adenoma of the Salivary Glands: Distinct Clinicopathologic Features and Immunoprofiles Between Subgroups According to Cellular Differentiation
Journal of Korean Medical Science ; : 1277-1285, 2011.
Article in English | WPRIM | ID: wpr-127700
ABSTRACT
In carcinoma ex pleomorphic adenoma (CXPA), pleomorphic adenoma (PA) and diverse carcinoma components showing luminal (ductal) or non-luminal (myoepithelial) differentiation coexist. To elucidate the clinicopathological implications of cellular differentiation in CXPA and the potential role of p53, vascular endothelial growth factor (VEGF), c-erbB-2, c-kit, and glucose transporter 1 (Glut-1) in carcinogenesis, we analyzed 11 CXPAs with luminal differentiation (CXPAs-LD) and 6 CXPAs with non-luminal differentiation (CXPAs-NLD) and compared protein expressions in residual PAs and carcinomas by immunohistochemistry. Among the CXPAs-LD, 5 were invasive and 8 were histologically high-grade tumors. The 5-year survival rate was 72.7%. P53, c-erbB-2, VEGF, and Glut-1 were more immunoreactive in carcinoma components than in PAs (P = 0.008, 0.004, 0.002, and 0.024, respectively); c-erbB-2 overexpression was associated with high histological grade (P = 0.024). Carcinoma components frequently lacked c-kit expression (P = 0.009). CXPAs-NLD were all low-grade and invasive with a larger mean tumor size (5.2 cm) than CXPAs-LD (3.3 cm) (P = 0.040). The patients remained disease-free without significant immunohistochemical expression. The immunoprofiles and clinical course of CXPA differed according to cellular differentiation. Therefore, it is important to report the histological subtype and to assess potential biomarkers in diagnostic and therapeutic trials.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Salivary Gland Neoplasms / Carcinoma / Biomarkers, Tumor / Cell Differentiation / Tumor Suppressor Protein p53 / Adenoma, Pleomorphic / Receptor, ErbB-2 / Proto-Oncogene Proteins c-kit / Vascular Endothelial Growth Factor A / Glucose Transport Proteins, Facilitative Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Salivary Gland Neoplasms / Carcinoma / Biomarkers, Tumor / Cell Differentiation / Tumor Suppressor Protein p53 / Adenoma, Pleomorphic / Receptor, ErbB-2 / Proto-Oncogene Proteins c-kit / Vascular Endothelial Growth Factor A / Glucose Transport Proteins, Facilitative Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2011 Type: Article