Subconjunctival Juvenile Xanthogranuloma Involving the Limbus Associated with Neurofibromatosis
Journal of the Korean Ophthalmological Society
; : 1733-1736, 2005.
Article
in Ko
| WPRIM
| ID: wpr-127732
Responsible library:
WPRO
ABSTRACT
PURPOSE: To report a case of isolated subconjunctival juvenile xanthogranuloma invading the corneal limbus in a patient with neurofibromatosis. METHODS: A 2-year-old boy visited the hospital with a conjunctival yellow-brown, non-tender mass of the left eye, which had been found 2 months earlier. Anterior segment examination revealed a 9 x 7 mm-sized subconjunctival elevated mass with an ill-defined border, invading the supero-temporal limbus. Additional ophthalmic examinations did not show any abnormal findings. In the trunk and extremities, there were multiple soft nodules and brown macules. An excisional biopsy of the subconjunctival mass, histopathologic and immunohistochemical examinations were performed. RESULTS: The mass was adhered to the episcleral tissue, without scleral or conjunctival involvement. The histological examination showed a granulomatous lesion consisting of multiple lipid-laden macrophages and other inflammatory cells. The immunohistochemical study showed positive staining for CD68 and negative staining for S100 protein. The multiple soft nodules and brown macules in the trunk and extremities were identified as neurofibromas and caf -au-lait macules by a dermatologist, and the patient was diagnosed with neurofibromatosis. CONCLUSIONS: We report a rare case of subconjunctival juvenile xanthogranuloma involving the limbus, associated with neurofibromatosis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Biopsy
/
Negative Staining
/
Limbus Corneae
/
Xanthogranuloma, Juvenile
/
Neurofibromatoses
/
Extremities
/
Macrophages
/
Neurofibroma
Type of study:
Prognostic_studies
Limits:
Child, preschool
/
Humans
/
Male
Language:
Ko
Journal:
Journal of the Korean Ophthalmological Society
Year:
2005
Type:
Article